The Oncology Department is seeking a Senior Research Specialist who will be involved in the design and analysis of experiments using primary human samples as well as utilization of in vitro and in vivo models. The position will be responsible for successful implementation of next-generation sequencing, single-cell RNA sequencing and single cell multiomics to characterize the impact of somatic mutations on bone marrow and peripheral blood obtained from patients with clonal hematopoiesis. Will also be involved in in vitro and in vivo modeling to further define the impact of somatic mutations on hematopoiesis. This position will be presenting the results at weekly lab meetings and present the data at national and international meetings. The position will also be expected to publish data in peer-reviewed journals.

Specific Duties & Responsibilities:

Performs and supervises laboratory experiments, particularly next-generation sequencing techniques, single-cell processing for various multiomics techniques.
Performs and supervises in vitro experiments using primary human bone marrow cells and cell lines, knockout and knockdown experiments using lentiviral delivery.
Works closely with institutional collaborators to provide technical and logistic support for clinical sample (blood, bone marrow, plasma) processing, analysis, data generation and maintenance of de-identified clinical information databases.
Performs flow cytometry on primary cells from patients and mice.
Reviews techniques and research protocols to ensure reproducibility and issues recommendations.
Works with laboratory staff to evaluate their technical knowledge and skills and assists in the training of other laboratory personnel.
Acts as a lead technical authority overseeing laboratory staff and is responsible for the overall daily operation of the laboratory including workload and personnel scheduling, quality control, inventory, and equipment maintenance.
Acts as the direct point of contact for industrial supplier sales personnel and technical support for both lab equipment and shared equipment which the lab uses extensively.
Supports research projects of students, fellows and other lab members as and when required.

Minimum Qualifications (Mandatory):

Bachelor's Degree in Biology, Biochemistry or related field. Master's Degree preferred.
4 years of relevant laboratory experience.
Additional related experience may substitute for required education to the extent permitted by the JHU Equivalency Formula.*

* JHU Equivalency Formula: 18 graduate degree credits may substitute for one year of experience.  Additional related experience may substitute for the required education on the same basis. For jobs where equivalency is permitted, up to two years of non-related college course work may be applied towards the total minimum education/experience required for the respective job.

** Applicants who do not meet the posted requirements but are completing their final academic semester/quarter will be considered eligible for employment and may be asked to provide additional information confirming their academic completion date.

Special Knowledge, Skills, or Abilities:

Excellent mammalian cell or cell line culture skills.
Experience in basic molecular biology techniques such as PCR, qPCR, DNA and RNA extraction.
Experience with various analytical methodologies including but not limited to flow cytometry, PCR, qPCR, cfDNA extraction, Western-blotting. If not conversant, expectation is for candidate to get acquainted with the technology and become independent within 6 months of joining.
Knowledge of human bone marrow cells isolation and processing.
Excellent record keeping, organizational, written and verbal skills.
Able to set up assays and conduct technical troubleshooting analysis.
Able to analyze data and provide a critical interpretation of results.
Ability to handle multiple priorities in a fast-paced environment.
Strong interpersonal skills.

Classified Title: Sr. Research Specialist
Role/Level/Range: ACRP/04/MC
Starting Salary Range: $45,650 - $62,850 annually (commensurate with experience)
Employee group: Full Time
Schedule: M-F 8:00am-4:30pm
Exempt Status: Exempt
Location: School of Medicine Campus
Department name: SOM Onc Hematologic Malignancies
Personnel area: School of Medicine

The successful candidate(s) for this position will be subject to a pre-employment background check.

If you are interested in applying for employment with The Johns Hopkins University and require special assistance or accommodation during any part of the pre-employment process, please contact the Talent Acquisition Office at jhurecruitment@jhu.edu. For TTY users, call via Maryland Relay or dial 711.

Johns Hopkins has mandated COVID-19 and influenza vaccines, as applicable. Exceptions to the COVID and flu vaccine requirements may be provided to individuals for religious beliefs or medical reasons. Requests for an exception must be submitted to the JHU vaccination registry. For additional information, applicants for SOM positions should visit https://www.hopkinsmedicine.org/coronavirus/covid-19-vaccine/ and all other JHU applicants should visit https://covidinfo.jhu.edu/health-safety/covid-vaccination-information/.

The following additional provisions may apply, depending on campus. Your recruiter will advise accordingly.

The pre-employment physical for positions in clinical areas, laboratories, working with research subjects, or involving community contact requires documentation of immune status against Rubella (German measles), Rubeola (Measles), Mumps, Varicella (chickenpox), Hepatitis B and documentation of having received the Tdap (Tetanus, diphtheria, pertussis) vaccination. This may include documentation of having two (2) MMR vaccines; two (2) Varicella vaccines; or antibody status to these diseases from laboratory testing. Blood tests for immunities to these diseases are ordinarily included in the pre-employment physical exam except for those employees who provide results of blood tests or immunization documentation from their own health care providers. Any vaccinations required for these diseases will be given at no cost in our Occupational Health office.

Note: Job Postings are updated daily and remain online until filled.

Equal Opportunity Employer

All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, or status as a protected veteran.

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About Johns Hopkins University

Johns Hopkins University remains committed to its founding principle, that education for all students should be grounded in exploration and discovery. Hopkins students are challenged not just to learn but also to advance learning itself. Critical thinking, problem solving, creativity, and entrepreneurship are all encouraged and nourished in this unique educational environment. After more than 130 years, Johns Hopkins remains a world leader in both teaching and research. Faculty members and their research colleagues at the university's Applied Physics Laboratory have each year since 1979 won Johns Hopkins more federal research and development funding than any other university. The university has nine academic divisions and campuses throughout the Baltimore-Washington area. The Krieger School of Arts and Sciences, the Whiting School of Engineering, the School of Education and the Carey Business School are based at the Homewood campus in northern Baltimore. The schools of Medicine, Public Health, and Nursing share a campus in east Baltimore with The Johns Hopkins Hospital. The Peabody Institute, a leading professional school of music, is located on Mount Vernon Place in downtown Bal...timore. The Paul H. Nitze School of Advanced International Studies is located in Washington's Dupont Circle area.

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